Cystic fibrosis on the African continent

Cystic Fibrosis in the African Diaspora.

Identifying mutations that cause cystic fibrosis (CF) is important for making an early, unambiguous diagnosis, which, in turn, is linked to better health and a greater life expectancy. In patients of African descent, a molecular diagnosis is often confounded by the fact that the majority of investigations undertaken to identify causative mutations have been conducted on European populations, an...

Continent-wide attack launched on African trypanosomiasis.

Priority pharmacogenetics for the African continent: Focus on Cytochrome P450

Countries in Africa have a high burden of communicable disease, and are experiencing an increase in non-communicable diseases due to the effects of globalization, industrialization and urbanization. The costs incurred through adverse drug reactions and non-responsiveness to therapy further aggravate the situation, and the application of pharmacogenetic principles is likely to provide some relie...

Surveillance and management of influenza on the African continent.

EVALUATION OF: Yazdanbakhsh M, Kremsner PG. Influenza in Africa. PLoS Med. 6(12), e1000182 (2009). The African continent is burdened with a very heavy load of communicable diseases over and above other severe health problems. Not surprisingly, influenza has received relatively little attention on the continent even though it is, in its own right, a major cause of morbidity and mortality--to a m...

The Influence of Genetics on Cystic Fibrosis Phenotypes Subject Collection Cystic Fibrosis The Cystic Fibrosis of Exocrine Pancreas

Perspective The Cystic Fibrosis Gene: A Molecular Genetic Lap-Chee Tsui and Ruslan Dorfman Cystic Fibrosis Status of Fluid and Electrolyte Absorption in M.M. Reddy and M. Jackson Stutts Anion Permeation The CFTR Ion Channel: Gating, Regulation, and Tzyh-Chang Hwang and Kevin L. Kirk Phenotypes The Influence of Genetics on Cystic Fibrosis Michael R. Knowles and Mitchell Drumm CFTR Assessing the ...